In a clip of Oprah Winfrey’s interview with the couple, Meghan had been asked how she felt about the palace hearing her “speak your truth today”.
Meghan also said: “If that comes with the risk of losing things, I mean… there is a lot that has been lost already.”
Buckingham Palace is investigating claims the duchess bullied royal staff.
The interview with Winfrey, which will air in the US on Sunday and in the UK on Monday, is expected to detail Harry and Meghan’s short period as working royals together before they stepped down for a life in the US.
In the 30-second teaser clip released by CBS, Winfrey asks the duchess: “How do you feel about the palace hearing you speak your truth today?”
Meghan replies: “I don’t know how they could expect that, after all of this time, we would still just be silent if there is an active role that The Firm is playing in perpetuating falsehoods about us.”
The Duke and Duchess of Sussex quit their roles as senior working royals in March 2020, and now live in California.
‘Attack on her character’
The allegations of bullying levelled at Meghan were published after the interview with Winfrey was recorded.
A report in the Times newspaper on Wednesday claimed the duchess faced a complaint when she was a working royal.
According to the story, it was made in October 2018, while the duke and duchess were living at Kensington Palace after their marriage in May of that year.
A leaked email sent from a staff member, which was published by the newspaper, alleges that Meghan drove two personal assistants out of the household. The report claims she undermined the confidence of a third member of staff.
In a statement later, Buckingham Palace – which is responsible for the hiring of royal staff – said it was “clearly very concerned about allegations in the Times” and its HR team would look into the circumstances outlined in the article.
“The Royal Household has had a Dignity at Work policy in place for a number of years and does not and will not tolerate bullying or harassment in the workplace.”
Past and present royal employees are to be invited to speak in confidence about their experiences of working for Meghan as part of the investigation.
The bullying allegations are denied by Meghan and Prince Harry.
A statement issued by Meghan’s spokesman in response to the newspaper’s story said: “The duchess is saddened by this latest attack on her character, particularly as someone who has been the target of bullying herself and is deeply committed to supporting those who have experienced pain and trauma.
“She is determined to continue her work building compassion around the world and will keep striving to set an example for doing what is right and doing what is good.”